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Bach: The Art of Fugue / Die Kunst Der Fuge

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Bach: The Art of Fugue / Die Kunst Der Fuge

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Editorial Reviews

Amazon.com

Everything about The Art of Fugue is controversial. Did Bach finish it or not? If not, should a completion be attempted, or should the finale fugue be left in its unfinished state? What order should the various pieces be played in? Where they intended to be listened to at all? And if "yes," what instrument would Bach have preferred? The answers to all of these questions are: "We don't know, and it really doesn't matter." Supremely practical musician that he was, Bach never wrote a note that he didn't intend to be heard, and if he didn't specify an instrument, that's because the music works just like the fugues themselves--backwards, forwards, upside-down and sideways. Marie-Claire Alain is one of the great Bach players of her age, and this performance is in every way worthy of her. --David Hurwitz

Bach: The Art of Fugue / Die Kunst Der Fuge

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Next-Generation Sequencing Drives Progress in Biopharma

Bioscience is a vast puzzle, which sounds like fun—until you remember that puzzles can be frustrating, especially if they’re missing crucial pieces. Fortunately, as this issue of GEN indicates, some of bioscience’s missing pieces are falling into place. Piece one: The tissue-level patterns formed by cells with disparate gene expression profiles. (These patterns, which influence health, are emerging because single-cell technology is being combined with spatial transcriptomics.) Piece two: A smooth Design-Build-Test-Learn (DBTL) cycle in synthetic biology. (DBTL still isn’t turning as freely as it might, but with new DNA-writing technology, more RPMs are expected.) Piece three: CAR T cells that could help more than a minority of cancer patients. (Such cells may be built if allogeneic approaches are used, or if genetic engineering is used to install ancillary immune signals.) So, if you want to solve bioscience puzzles—including those related to outsourcing and bringing NGS to bear in biomanufacturing—read our September issue.

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